Abstract Polyketide synthases (PKSs) are crucial multidomain enzymes in diverse natural product biosynthesis.Parrots use a type I PKS to produce a unique pigment called psittacofulvin in their feathers.In domesticated budgerigars and lovebirds, the same amino acid substitution (R644W) within malonyl/acetyltransferase (MAT) domain of this enzyme has
MicroRNAs (miRNAs) can regulate tumor cell invasion and metastasis in a tumor-specific manner.We recently demonstrated that global downregulation of miRNAs after deleting dicer can promote development of distant metastases in a mouse model of primary soft tissue sarcoma (STS).In this study, we identified miRNAs that are differentially downregulated
Abstract.The COVID-19 pandemic has acutely challenged health systems and catalyzed the need for widescale virtual care and digital solutions across all areas of health, including pediatric chronic pain.The objective of this rapid systematic review was to identify recommendations, guidelines, and/or best practices for using virtual care to support y
Ring spot, caused by the fungus Leptosphariea sacchari, is a disease of sugarcane that has been known to occur in Florida for over 80 years.Ring spot usually affects only the older leaves, and therefore is considered hot priest costume a minor disease.However, correctly identifying the disease in the field can help to reduce unnecessary chemical sp
hot priest costume This article proves that social protection is an effective tool for reducing poverty, contributing to the integration of economic and social aspects of sustainable development.The main purpose of this study is to evaluate the current state of the social protection system in the Republic of Kazakhstan and to develop measures to im